Vomit Cone
Tank: She targets you with a very wide, very long poison cone that tracks you. Face it away from the group and hold near the edge of the arena, with your back to the wall, to leave everyone else room.
Vomit Cone spillover
All: If the Vomit Cone catches anyone other than the tank, that player uncontrollably spews poison in front of themselves for a few seconds. Stay clear of anyone this happens to.
Poison Storm
All: At 70% and 35% health she fills the whole room with a poison effect. Everyone needs healing through it for a few seconds.
Time Stop synergy
All: Take the synergy that appears after Poison Storm. It clears the poison and stuns the adds for a few seconds.
Poison Storm adds
Dps: Focus the adds while they are stunned by the Time Stop synergy. They take extra damage during it, so it is worth saving an ultimate for this window.
Peryite's Glory
Tank: Taunt the Peryite's Glory adds, the green blobs, as they spawn through the fight.
Dps: The Peryite's Glory adds should die to normal cleave and area damage. If the group's area damage is weak, focus them down directly rather than letting them drain the tank.
Invulnerable Poison Storm adds
Dps: Hard Mode only. Adds during Poison Storm are fully invulnerable, rather than merely resistant, until the Time Stop synergy stuns them. That window is the only time to kill them, so save ultimates for it if needed.
Skeever Bite / Skeevers (Hard Mode)
Tank: Hard Mode only. Help control the Skeever summoned periodically, using crowd control such as a pull or a root. It locks onto a player (marked with a red rune) and cannot be taunted.
Healer: Hard Mode only. A red rune above your head means a Skeever is locked onto you. Kite it away to give the group time to kill it before it reaches you and applies Skeever Bite, a crippling debuff that dramatically increases the resource cost of all abilities.
Dps: Hard Mode only. A red rune above your head means a Skeever is locked onto you. Kite it away while others burn it; if it touches its target, it applies Skeever Bite, dramatically increasing all ability resource costs. CC and burn it immediately.